Bridging the Gap

School districts across the country are increasingly seeking out digital tools to support the work of educators, in the hopes of improving students' academic achievement. With the rapid emergence of this new market, many districts have been challenged by the task of identifying and procuring educational technology (ed-tech) products that match the needs of their educators and students.The NYC Department of Education's "Innovate NYC Schools" division, supported by a U.S. DOE Investing in Innovation (i3) grant, aims to address this problem, in part by promoting "user-centered design," an approach that puts the needs and preferences of products' intended users (in this case, teachers, students, and parents) front and center in the development and procurement of new technology.Bridging the Gap describes the design and implementation of three Innovate NYC Schools initiatives grounded in user-centered design theory:School Choice Design Challenge (SCDC),an effort to develop apps that would help students explore and narrow down their choices of high school.#SharkTankEDU events, during which ed-tech developers present a product to a panel of educators who provide feedback on the tool.Short-Cycle Evaluation Challenges (SCEC), a classroom-based, semester-long pilot of ed-tech tools intended to inform product development, as well as the ultimate procurement decisions of school staff.The report focuses on four phases of work involved in bringing ed-tech companies and the users of their products together: defining a problem; selecting users and ed-tech companies; implementing pilot-based initiatives; and evaluating products. It describes strategies used and challenges faced, and offers practical lessons gleaned from the experiences of the individuals who designed and participated in these efforts.

Preliminary Evaluation of a Laparoscopic Common Bile Duct Simulator for Pediatric Surgical Education

Purpose: Laparoscopic common bile duct exploration (LCBDE) decreases overall costs and length of stay in patients with choledocolithiasis. However, utilization of LCBDE remains low. We sought to evaluate a previously developed general surgery LCBDE simulator among a cohort of pediatric surgical trainees. The study purpose was to evaluate the content validity of an LCBDE simulator to support or refute its use in pediatric surgery education. Materials and Methods: After IRB exempt determination, 30 participants performed a transcystic LCBDE using a previously developed simulator and evaluated the simulator using a self-reported 28-item instrument. The instrument consisted of two primary domains (Quality and Ability to Perform) that were rated using twenty-five 4-point rating scales and one 4-point global rating scale. Validity evidence relevant to test content was evaluated using a many-facet Rasch model. Interitem consistency was estimated using Cronbach's alpha. P?Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140153/1/lap.2016.0248.pd

Effects of adjunctive eslicarbazepine acetate on serum lipids in patients with partial-onset seizures: Impact of concomitant statins and enzyme-inducing antiepileptic drugs.

PURPOSE: To evaluate the effects of eslicarbazepine acetate (ESL) on lipid metabolism and to determine whether reduced statin exposure during ESL therapy has clinical consequences. SUBJECTS AND METHODS: We conducted a post-hoc analysis of pooled data for serum lipids (laboratory values) from three phase III, multicenter, randomized, double-blind, placebo-controlled trials of adjunctive ESL therapy (400, 800, or 1200 mg once daily) in patients with treatment-refractory partial-onset seizures. Changes from baseline in serum lipid levels were analyzed according to use of statins and/or enzyme-inducing antiepileptic drugs (EIAEDs) during the baseline period. KEY FINDINGS: In total, 426 and 1021 placebo- and ESL-treated patients, respectively, were included in the analysis. With regard to the changes from baseline in serum concentrations, there were statistically significant differences between the placebo and ESL 1200 mg QD groups, for both total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C), but the effect sizes were small (+4.1 mg/dL and +1.8 mg/dL, respectively). A small but significant difference in low-density lipoprotein cholesterol (LDL-C; -5.0 mg/dL) was observed between the ESL 400 mg QD group and the placebo group. In patients not taking a concomitant EIAED, there were no changes with ESL 400 mg QD, but modest and statistically significant increases in cholesterol fractions (TC, LDL-C and HDL-C) with ESL 800 mg QD (/dL) and ESL 1200 mg QD (/dL). ESL had no consistent effect on lipids in patients taking a concomitant EIAED. In patients taking statins during baseline, there were no clinically relevant changes in serum lipids during use of ESL, although the subgroups were small. SIGNIFICANCE: These results suggest that ESL does not appear to have clinically significant effects on serum lipids, nor does the pharmacokinetic interaction between ESL and statins have an impact on serum lipid concentrations

Giant Relaxation Oscillations in a Very Strongly Hysteretic SQUID ring-Tank Circuit System

In this paper we show that the radio frequency (rf) dynamical characteristics of a very strongly hysteretic SQUID ring, coupled to an rf tank circuit resonator, display relaxation oscillations. We demonstrate that the the overall form of these characteristics, together with the relaxation oscillations, can be modelled accurately by solving the quasi-classical non-linear equations of motion for the system. We suggest that in these very strongly hysteretic regimes SQUID ring-resonator systems may find application in novel logic and memory devices.Comment: 7 pages, 5 figures. Uploaded as implementing a policy of arXiving old paper

The Future of Leisure Studies in Research Universities: Administrators\u27 Perspectives

This article summarizes the content of a three-day administrative summit held at Zion Ponderosa Resort in southern Utah in late September 2010. Department chairs, heads, and deans representing 13 universities across North America offering leisure studies doctoral degrees, master\u27s degrees, and undergraduate professional preparation degrees gathered to entertain eight multifaceted questions pertaining to their future. The questions were generated by a Delphi Process, and responses to the questions were recorded and analyzed following the summit by a team of doctoral students and professors from the University of Utah. The article concludes with a brief discussion of an administrator\u27s responsibility in leading leisure studies departments in times of fiscal austerity, and recommending a to-do list to ensure the future of leisure studies in public research universities

Network formation mechanisms in conjugated microporous polymers

We discuss in detail the mechanism of formation of a highly microporous polymer, CMP-1, formed mainly via Sonogashira–Hagihara coupling. We demonstrate how the microporosity evolves with time, and discuss the importance of alkyne homo-coupling on the microporosity

Aneuploidy in cancer:Lessons from acute lymphoblastic leukemia

Altres ajuts: We are indebted to all the members of the laboratory of P.M. for their insights. Special thanks to Dr Isabel Granada (Hematology laboratory at Germans Trias i Pujol Hospital, Catalan Institute of Oncology, Badalona, Spain), Dr Paola Ballerini (Hopital Trousseau, Paris, France), and Drs Nassera Abermil and Chrystele Bilhou-Nabera (Saint Antoine Hospital, Paris, France) for providing the karyotype images. We thank Dr A.A. Jeyaprakash (Wellcome Trust Centre for Cell Biology, University of Edinburgh, Edinburgh, UK) for critical revision of the MS. We thank Centres de Recerca de Catalunya (CERCA)/Generalitat de Catalunya, the Fundació Josep Carreras, and the Obra Social 'la Caixa' for their institutional support. Work in the laboratory of P.M. is supported by Spanish Ministry of Cience and Innovation, the European Research Council (CoG-2014-646903 and PoC-2018-811220), the Spanish Ministry of Economy and Competitiveness , the Fundación Uno entre Cienmil, and the Fundación Leo Messi. F.S. is supported by Instituto de Salud Carlos III, the Spanish Ministry of Economy and Competitiveness and (GRC). We also thank the Wellcome Trust for supporting M.A.A. through a Senior Research Fellowship to A.A. Jeyaprakash (202811). P.M. is an investigator of the Spanish Cell Therapy Cooperative Network (TERCEL).Aneuploidy, the gain or loss of chromosomes in a cell, is a hallmark of cancer. Although our understanding of the contribution of aneuploidy to cancer initiation and progression is incomplete, significant progress has been made in uncovering the cellular consequences of aneuploidy and how aneuploid cancer cells self-adapt to promote tumorigenesis. Aneuploidy is physiologically associated with significant cellular stress but, paradoxically, it favors tumor progression. Although more common in solid tumors, different forms of aneuploidy represent the initiating oncogenic lesion in patients with B cell acute lymphoblastic leukemia (B-ALL), making B-ALL an excellent model for studying the role of aneuploidy in tumorigenesis. We review the molecular mechanisms underlying aneuploidy and discuss its contributions to B-ALL initiation and progression

Sustainable Turf Management

Report completed by students enrolled in HORT 4061: Turfgrass Management, taught by Eric Watkins in fall 2014.This project was completed as part of a year-long partnership between the City of Rosemount and the University of Minnesota’s Resilient Communities Project (http://www.rcp.umn.edu). The City of Rosemount is home to more than 30 parks, yet has only four staff working to maintain them. With limited time and expertise to determine and respond to the unique needs of each park and recreation facility in the city, the Public Works Department had mostly standardized their maintenance techniques. The goal of this project was to identify more effective and efficient long-term maintenance techniques for parks within the City of Rosemount in order to better preserve its natural public spaces and promote active living as the population grows. In collaboration with Jim Koslowski, Public Works Supervisor for the City of Rosemount, and Tom Schuster, Parks Supervisor for the City of Rosemount, four teams of students in HORT 4061: Turfgrass Management analyzed the soil, plant species, and drainage patterns at four different parks—the Dakota County Technical College Ames Soccer Complex, Brockway Disc Golf Course, Innisfree Park, and Meadows Park—and provided recommendations for how best to restore and maintain turf at these facilities. A combined final report from the project including links to brief YouTube videos on each of the parks is available.This project was supported by the Resilient Communities Project (RCP), a program at the University of Minnesota that convenes the wide-ranging expertise of U of M faculty and students to address strategic local projects that advance community resilience and sustainability. RCP is a program of the Center for Urban and Regional Affairs (CURA). More information at http://www.rcp.umn.edu

The Glial Regenerative Response to Central Nervous System Injury Is Enabled by Pros-Notch and Pros-NFκB Feedback

Organisms are structurally robust, as cells accommodate changes preserving structural integrity and function. The molecular mechanisms underlying structural robustness and plasticity are poorly understood, but can be investigated by probing how cells respond to injury. Injury to the CNS induces proliferation of enwrapping glia, leading to axonal re-enwrapment and partial functional recovery. This glial regenerative response is found across species, and may reflect a common underlying genetic mechanism. Here, we show that injury to the Drosophila larval CNS induces glial proliferation, and we uncover a gene network controlling this response. It consists of the mutual maintenance between the cell cycle inhibitor Prospero (Pros) and the cell cycle activators Notch and NFκB. Together they maintain glia in the brink of dividing, they enable glial proliferation following injury, and subsequently they exert negative feedback on cell division restoring cell cycle arrest. Pros also promotes glial differentiation, resolving vacuolization, enabling debris clearance and axonal enwrapment. Disruption of this gene network prevents repair and induces tumourigenesis. Using wound area measurements across genotypes and time-lapse recordings we show that when glial proliferation and glial differentiation are abolished, both the size of the glial wound and neuropile vacuolization increase. When glial proliferation and differentiation are enabled, glial wound size decreases and injury-induced apoptosis and vacuolization are prevented. The uncovered gene network promotes regeneration of the glial lesion and neuropile repair. In the unharmed animal, it is most likely a homeostatic mechanism for structural robustness. This gene network may be of relevance to mammalian glia to promote repair upon CNS injury or disease

Computational strategies for dissecting the high-dimensional complexity of adaptive immune repertoires

The adaptive immune system recognizes antigens via an immense array of antigen-binding antibodies and T-cell receptors, the immune repertoire. The interrogation of immune repertoires is of high relevance for understanding the adaptive immune response in disease and infection (e.g., autoimmunity, cancer, HIV). Adaptive immune receptor repertoire sequencing (AIRR-seq) has driven the quantitative and molecular-level profiling of immune repertoires thereby revealing the high-dimensional complexity of the immune receptor sequence landscape. Several methods for the computational and statistical analysis of large-scale AIRR-seq data have been developed to resolve immune repertoire complexity in order to understand the dynamics of adaptive immunity. Here, we review the current research on (i) diversity, (ii) clustering and network, (iii) phylogenetic and (iv) machine learning methods applied to dissect, quantify and compare the architecture, evolution, and specificity of immune repertoires. We summarize outstanding questions in computational immunology and propose future directions for systems immunology towards coupling AIRR-seq with the computational discovery of immunotherapeutics, vaccines, and immunodiagnostics.Comment: 27 pages, 2 figure